Sonic Hedgehog in immune/embryology Development of Mammals

thymocyte development in Shh-/-

CD45 receptor is expressed by all cells with a leukocyte lineage. Anti-CD25, and Anti-CD44 staining were gated on CD45 to determine relative thymocyte numbers. Shh mutants. Shh-/- Displayed low numbers of thymocytes in general(A) as well as CD45(B) and CD25(C) thymocytes, suggesting that knockout of the gene reduced thymocyte proliferation.

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