Foxp3: Important regulatory gene for the development of regulatory T-cells

FOXP3 Mutations

Figure 4: Mutations in the gene FOXP3, have been found in IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome) and XLAAD (X-Linked Autoimmunity-Allergic Disregulation) patients as well as scurfy mice. TReg cells inhibit CD4+ causing the prevention of these disorders (O’Garra et al. 2003).

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