How do patterns develop in nature? How do digits develop on a limb? ~ Hox genes are the answer.

Figure 3

Manipulation of Gli3 and multiple Hox genes causes severe polydactyly. The Turing model correctly predicts phenotypes for various mutants.

Figure 3: The phenotypes of triple mutants can be replicated by the Turing model. (Top) The first three rows show Sox9 expression at E12.5 and E13.5 for different combinations of the triple Hoxa13;Hoxd11-13;Gli3 allelic series. As more Hox are removed, the general trend shows an increase in digit number and a decrease in digit thickness. The trend is most strongly evident in the complete absence of Gli3 (third row). (Bottom) A similar behavior is shown by the reaction-diffusion simulations, where a decrease of the PD gradient used to modulate wavelength is correlated with reduced Hox dose (khox). Additionally, the model predicts a narrower digital region along the PD axis, which eventually shrinks to zero, and no pattern is formed. Figure and legend from Sheth et al. 2012.

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