The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo


Fig. 2. kin-18(RNAi) delay in pseudocleavage relaxation does not depend on the cell cycle delay. (A) Stills from DIC time-lapse recordings of the indicated genotypes, PNM time is set to 0 s. White arrowheads indicate the site of pseudocleavage ingression. (B) Quantification of pseudocleavage persistence and PNM to NEBD timing in the indicated genotypes. *p<0.005 with respect to control RNAi (control RNAi n=8, kin-18(RNAi) n=9, div-1(RNAi) n=11, atl-1(tm853) n=11, kin-18(RNAi); atl-1(tm853) n=11, div-1(RNAi); atl-1(tm853) n=8). Averages are shown, error bars represent s.e.m., scale bars 10 μm. The difference in time of pseudocleavage persistence between KIN-18 depletion in WT and in the atl-1(tm853) mutant is not statistically significant (p=0.174).

Bookmark the permalink.

Leave a Reply

Your email address will not be published. Required fields are marked *